Biomarker Analytical Core

Formerly the Hypertension Core Laboratory


Overview of Services 


The Biomarker Analytical Core (BAC) at Wake Forest School of Medicine is a CLIA-certified laboratory that performs clinical and research assays.  It serves as a reference laboratory for Wake Forest Baptist Medical Center, Winston-Salem, NC, as well as a central laboratory for Hypertension and Vascular Research.  The laboratory has participated in NIH, FDA, and pharmaceutical company-sponsored studies and has experience with multi-center projects.  K. Bridget Brosnihan, Ph.D. is certified as a high complexity assay laboratory director.  
The BAC provides analytical support for individual projects and for program project grants within the institution, as well as for national and international investigators.

The majority of the analytes are measured by radioimmunoassay (RIA), enzyme immunoassay (EIA), and enzymatic assays.  By having all the samples analyzed by staff with long-term experience, in a single laboratory equipped with appropriate instrumentation, data can be obtained in a more uniform manner, with the strictest possible quality control and minimal reagent expense.
The BAC is nationally and internationally recognized as an expert in measurement of components of the renin-angiotensin system, and provides biomarkers of cardiovascular, inflammatory, and aging-related and metabolic diseases.


  • Radioimmunoassay (RIA)
  • Enzyme Immunoassays (EIA)
  • Standard and Customized Multiplex ELISAS
  • High-Performance Liquid Chromatography (HPLC)
  • Mass spectrometry
  • Data analysis and consulting

Our Menu of Assays Include:

  • Hypertension Risk and Renal Injury Markers
  • Cytokines, Chemokines and Adhesion Molecules
  • Obesity and Metabolics Hormones
  • Stress, Aging and Inflammatory Markers
  • Vasoactive Peptides and Hormones
  • Sex Hormones


K. Bridget Brosnihan, PhD, HCLD
Phone: (336) 716-2795

TanYa Gwathmey-Williams, PhD

Phone: (336) 716-9524


Lab Contact 

Pam Dean
Lab Manager/Tech
Phone: (336)-716-3553


Location and Hours of Operation 

Hours Location

Monday - Friday

8:30 AM - 5:00 PM

Biomarker Analytical Core 
Biotech Place
575 N. Patterson Ave, 1S-Suite 134 
Winston, Salem, NC 27101

Links and Resources

  1. Biomarker Analytical Core Website


Name Role Phone Email Location
Pam Dean
Lab Manager
(336) 716-3553
Biotech Place
TanYa Gwathmey
(336) 716-9524
Biotech Place
K. Bridget Brosnihan
Professor, High Complexity Laboratory Director
(336) 716-2795
Biotech Place
Katie Busalacchi
Lab Tech
Biotech Place

Service list

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Assays (165)