iLab Organizer :: Crystallography and Computational Biosciences Core

Overview of Services

The Crystallography and Computational Biosciences Shared Resource serves as a portal for access to state-of-the-art X-ray crystallographic equipment, technical support, high-performance computing, and scientific consultation for Cancer Center researchers. The Shared Resource exists to meet the growing needs for structure determination and computational analysis of protein and DNA/RNA structure, function and dynamics for a diverse array of projects ranging from basic science questions to drug design.

The Structural Biology team has expertise in macromolecular crystallography and works with investigators on all levels of structure determination.

Consulting on all aspects of protein expression, purification, and feasibility of structure determination.

Identification of crystallization conditions and possible other existing structures.

Access to X-ray diffraction facility.

Determination of the molecular structure through collaboration.

Our Computational Bioscience expertise lies primarly in structure-based classical modeling, docking and analysis, but additional expertise exists in computational biology/bioinformatics, and in quantum mechanical calculations.

Consultation to determine if the problem is amenable to computation.

Decide what sort of computations need to be performed.

Calculations that we can readily perform include: molecular dynamics, protein-protein docking, and protein-ligand docking. Quantum mechanical calculations and other mathematical modeling may be possible.

Location and hours of operation

Hours	Locations
Mon - Fri: 8AM - 5PM	Wake Forest Biotech Place, Center for Structural Biology Department of Biochemistry Rooms 2W-020 and 2W-022 Olin Physical Laboratory, Department of Physics

Links and Resources

Save

Contacts

Name	Role	Email	Location
Dr. W. Todd Lowther	Director	tlowther@wakehealth.edu
Dr. Tom Hollis	Director	thollis@wakehealth.edu
Dr. Fred Salsbury	Director	salsbufr@wfu.edu	Olin Physical Laboratory