Metabolic Phenotyping Shared Resource (MPSR)

Overview of Services

Metabolic Phenotyping provides indirect calorimetry services in laboratory mice to academic and industrial investigators.

The MPSR is affiliated with Wake Forest's Center on Diabetes, Obesity, and Metabolism.

Our mission is to offer technical support and expertise for measuring traits related to metabolism in mouse models of obesity and nutritionally relevant diseases including aging, diabetes, cardiovascular disease, Alzheimer's disease, and cancer.

Our core provides access to state-of-the-art equipment, the TSE PhenoMaster system, to support high quality and high throughput phenotyping of energy balance components in mice. Variables provided by this system include food, drink, body weight, oxygen consumption, carbon dioxide production, respiratory ratio (the volume of carbon dioxide/oxygen), heat production, total energy expenditure, XYZ activity, and running wheels that can be enabled or disabled by time and distance. The Core also provides access to the environmental control chambers which are specifically designed for indirect calorimetry experiments using TSE PhenoMaster system. Temperature challenges (the temperature ranges from 4°C to 35°C) and circadian effects can be studied in detail.

In addition to the fee-for-service analyses, the MPSR offers options to accommodate various needs such as training and project-based collaborations.

Leadership

Location and hours of operation

Links and Resources

1. https://school.wakehealth.edu/research/institutes-and-centers/center-on-diabetes-obesity-and-metabolism/metabolic-phenotyping-shared-resource

Contacts